Mad Prime comments

"It's a Boy!: or How I Learned to Stop Worrying and Love Direct to Consumer Genomics" by Madeleine

Thu, 26 Jan 2012 08:11:41 -0500

What's hard to tell from this is that there's a whole X from Grandma that Mom *didn't* get -- if this is an X-linked mutation it could be anywhere on that other X chromosome. So there's only 5% of this X "untested" but 100% of the other X -- it could be anywhere in these. The chances it's hiding in the remaining 5% on this one is just 5 / 105 = 4.8%. ..... Note that 4.8% is still an improvement -- before we had this knowledge the estimate for both you and me was 10%. Also keep in mind there's a good chance (say 50%) this isn't X-linked in the first place. If we figured out what the exact mutation is in our uncles, we'd know whether or not you carry it -- because we'd know where it is. Depending on whether you carry it, you'd either have a 0% or 50% chance of passing it on to a son.

"It's a Boy!: or How I Learned to Stop Worrying and Love Direct to Consumer Genomics" by Suzy

Thu, 26 Jan 2012 01:16:29 -0500

Finally got around to reading this, although I had Dad explain it to me at home last week. Since then, I've been worried about the portion of the X chromosome that I got and Alex & Andrew haven't automatically tested by their existence (since they didn't have it). Does this mean I do carry the mutation (if a mutation is at fault) and testing our uncles means will just help me determine the matter of degree (in how likely the chance it will affect my children)?

"Oh Apple..." by Madeleine

Sat, 21 Jan 2012 15:30:28 -0500

Oops -- typo fixed, thanks for the heads up!

"Oh Apple..." by Benjamin Mako Hill

Sat, 21 Jan 2012 08:43:42 -0500

Unbelievable. Unfortunately, that page is unloadable. :-(

"I am a Ball bearing" by Samuel Jacob

Tue, 20 Dec 2011 20:20:22 -0500

Mad exciting!! Thank you for sharing those (very interesting) details. So "36 weeks" is really 34 weeks after fertilization? I look forward to captivating low-friction parenting updates in the months and years to come.

"Color Blindness" by Madeleine

Tue, 02 Feb 2010 00:40:09 -0500

R. Hahin: As noted at the bottom of the post, the graph of opsin light response curves is from http://en.wikipedia.org/wiki/File:Cones_SMJ2_E.svg Like most Wikipedia images, it is free for you to re-use under the Creative Commons attribution license. Please, consider my modified image to be free for re-use under the same Creative Commons license.

"Color Blindness" by R. Hahin

Tue, 02 Feb 2010 00:32:28 -0500

Dear Madeleine: I am a neurophysiologist who studies Na channels and agents that alter them. I also teach a class (Vision & the Visual System) about brain function and vision. I found a diagram of the three spectral absorbance curves for the three cone classes that would be helpful for my students on your site Mad Prime. I would appreciate your permission to use it in my classroom. Sincerely yours, R. Hahin, Ph.D.

"5% Irish Cream" by Brian Degger

Tue, 12 Jan 2010 14:29:21 -0500

so the next time my wife want to buy Baileys, I might be making up a hybridization buffer, with a small sample. BTW lovely graphics on wikipedia (how I found this site) Cheers B

"5% Irish Cream" by Benjamin Mako Hill

Sat, 19 Dec 2009 20:57:47 -0500

Awesome! You should submit this to NCIROFL.

"YouTube meme becomes scientific study!" by Brian Jordan

Wed, 30 Sep 2009 02:22:57 -0400

hahahaha!